Patents
1. S. Tasoglu, R. Amin, S. Knowlton, “Multi-layered paper-based microfluidic device for body fluid analysis”, Provisional application (2019).
2. U. Demirci, E. Kayaalp, H. Shafee, X. Zhang, S. Tasoglu, “Analysis and Sorting of Motile Cells”, WO Patent 2012162181 (2012). . Licensed by ZyMōt Fertility, Inc. (2014). In actively use by IVF clinics: 10k+ Babies.
3. S. Tasoglu, U. Demirci, “System and method for magnetic self-assembly”, US Patent App. 15/121,635. Licensed by LevitasBio, Inc. BioLevitas received $8m investment.
4. U. Demirci, I. Ghiran, S. Tasoglu, R.W. Davis, L. Steinmetz, N.G. Durmus, H.C. Tekin “System and method for cell levitation and monitoring”, US Patent App. 15/121,646. Licensed by LevitasBio, Inc. BioLevitas received $8m investment.
Peer-reviewed Publications
1) Portable Low-Cost Magnetic Levitation for Cell Sorting and Sickle Cell Diagnosis
Sickle Cell Diagnosis
1. B. Yenilmez., S. Knowlton., & S. Tasoglu*. “Self‐contained handheld magnetic platform for point of care cytometry in biological samples”. Advanced Materials Technologies, 1(9), 1600144 (2016).
a. Featured the backcover of the journal.
2. S. Knowlton, I. Sencan, Y. Aytar, J. Khoory, M.M. Heeney, I.C. Ghiran, S. Tasoglu*, “Sickle Cell Detection Using a Smartphone”, Scientific Reports, 5,15022 (2015).
a. Highlighted in several media outlets (https://tasoglulab.ku.edu.tr/media-coverage/).
3. S.M. Knowlton, B. Yenilmez, R. Amin, & S.Tasoglu*. “Magnetic Levitation Coupled with Portable Imaging and Analysis for Disease Diagnostics”. JoVE (Journal of Visualized Experiments), 120, e55012-e55012 (2017).
Cell Sorting
1. S. Knowlton, A. Joshi, P. Syrrist, A.F. Coskun, & S. Tasoglu*. “3D-printed smartphone-based point of care tool for fluorescence-and magnetophoresis-based cytometry”. Lab on a Chip, 17(16), 2839-2851 (2017).
2. R. Amin, S. Knowlton, J. Dupont, J.S. Bergholz, A. Joshi., A. Hart, B. Yenilmez, C. H. Yu, A. Wentworth. J.J. Zhao, & S. Tasoglu*. “3D-printed smartphone-based device for label-free cell separation” Journal of 3D Printing in Medicine 1(3) 155-164 (2017).
3. B. Yenilmez, S. Knowlton, C.H. Yu, M.M. Heeney and S. Tasoglu*, “Label-free Sickle Cell Disease Diagnosis Using a Low-Cost, Handheld Platform”, Advanced Materials Technologies, 1(5), 1600100 (2016).
4. R. Amin., S. Knowlton., B. Yenilmez., A. Hart., A. Joshi., & S. Tasoglu*. “Smart-phone attachable, flow-assisted magnetic focusing device”. RSC Advances, 6(96), 93922-93931 (2016).
5. S. Knowlton, C.H Yu, N. Jain, I.C. Ghiran, S. Tasoglu*, “Smart-Phone Based Magnetic Levitation for Measuring Densities”, PLoS ONE, 10(8), e0134400 (2015).
6. S. Tasoglu, J. Khoory, H.C. Tekin, I.C. Ghiran, U. Demirci, “Levitational Image Cytometry with Temporal Resolution”, Advanced Materials, 27 (26), 3901-3908 (2015).
a. Featured the frontispiece of the journal
2) Disposable Diagnostics
Urine Diagnostics
1. F. Ghaderinezhad, H.C. Koydemir, D. Tseng, D. Karinca, K. Liang, A. Özcan*, & S. Tasoglu*. “Sensing of electrolytes in urine using a miniaturized paper-based device”. Scientific Reports, 10 (1), 1-9 (2020).
Low-Cost Disposable Paper-based Microfluidics
1. R Amin, F Ghaderinezhad, C Bridge, M Temirel, S Jones, P Toloueinia, and S. Tasoglu*, “Pushing the Limits of Spatial Assay Resolution for Paper-Based Microfluidics Using Low-Cost and High-Throughput Pen Plotter Approach”, Micromachines 11 (6), 611 (2020).
2. R. Amin, F. Ghaderinezhad, L. Li, E. Lepowsky, B. Yenilmez, S. Knowlton, & S. Tasoglu*. “Continuous-Ink, Multiplexed Pen-Plotter Approach for Low-Cost, High-Throughput Fabrication of Paper-Based Microfluidics”. Analytical Chemistry 89(12):6351-6357 (2017).
3. F. Ghaderinezhad, R. Amin, M. Temirel, B. Yenilmez, A. Wentworth, & S. Tasoglu*. “High-throughput rapid-prototyping of low-cost paper-based microfluidics”. Scientific Reports, 7, 3553 (2017).
4. E Lepowsky, F Ghaderinezhad, S Knowlton, S. Tasoglu*. “Paper-based assays for urine analysis” Biomicrofluidics 11 (5), 051501 (2017).
3) Low-cost Microfluidic Platforms
Infectious Disease Diagnostics
1. S. Wang, S. Tasoglu, P. Chen, M. Chen, R. Akbas, U.A. Gurkan, F.F. Giguel, D.R. Kuritzkes, U. Demirci, “Micro-a-fluidics for Rapid Automated CD4 Cell Count at the Point-of-Care”, Scientific Reports, 4, 3796 (2014).
2. F. Inci, O. Tokel, S. Wang, U.A. Gurkan, S. Tasoglu, D.R. Kuritzkes, U. Demirci, “Nanoplasmonic Quantitative Detection of Intact Viruses from Unprocessed Whole Blood”, ACS Nano, 7 (6), 4733-45 (2013).
Men’s Health
1. S.M. Knobwlton, M. Sadasivam, S. Tasoglu*, “Microfluidics for Sperm Research” Trends in Biotechnology, 33(4), 221-229 (2015). Invited Article
a. Featured the cover of the journal.
b. Highlighted in several media outlets.
2. S. Tasoglu, H. Safaee, X. Zhang, J.L. Kingsley, P.N. Catalano, U.A. Gurkan, A. Nureddin, E. Kayaalp, R.M. Anchan, R.L. Maas, E. Tüzel, U. Demirci, “Exhaustion of racing sperm in nature-mimicking microfluidic channels during sorting”, Small, 9(20), 3366 (2013).
a. Highlighted in Nature Medicine, 19(4), 800 (2013).
b. Featured the inside cover of journal
c. Highlighted in Boston Magazine; Boston Globe; Boston.com; WPI and BWH News.
Women’s Health
1. S. Tasoglu*, H.C. Tekin, F. Inci, S. Knowlton, S.Q. Wang, F. Wang-Johanning, G. Johanning, D. Colevas, U. Demirci, “Advances in Nanotechnology and Microfluidics for Human Papillomavirus Diagnostics”, Proceedings of the IEEE 103 (2), 161-178 (2015). *Co-corresponding author.
2. S. Tasoglu, L.C. Rohan, D.F. Katz, A.J. Szeri, “Transient swelling, spreading and drug delivery by a dissolved anti-HIV microbicide-bearing film”, Physics of Fluids, 25(3), 031901 (2013).
a. Highlighted in American Institute of Physics, PoF Research Highlights.
3. S. Tasoglu, D.F. Katz, and A.J. Szeri, “Transient spreading and swelling behavior of a gel deploying an anti-HIV microbicide”, J. Non-Newtonian Fluid Mechanics, 187-188, 36-42 (2012).
4. S. Tasoglu, S.C. Park, J.J. Peters, D.F. Katz, A.J. Szeri, “The consequences of yield stress on deployment of a non-Newtonian anti-HIV microbicide gel”, J. Non-Newtonian Fluid Mechanics, 166, 1116-22 (2011).
5. S. Tasoglu, J.J. Peters, S.C. Park, S. Verguet, D.F. Katz, A.J. Szeri, “The effects of inhomogeneous boundary dilution on the coating flow of an anti-HIV microbicide vehicle”, Physics of Fluids, 23, 093101 (2011).
a. Selected for the September, 2011 issue of Virtual Journal of Biological Physics Research
3D Printed Low-Cost Microfluidics
1. S. Tasoglu*, and Albert Folch* “3D Printed Microfluidic Devices”, total page number: 211, Published: December 2018, Micromachines Press, ISBN 978-3-03897-467-3 (Pbk); ISBN 978-3-03897-468-0, https://doi.org/10.3390/books978-3-03897-468-0 (2018).
2. S. Tasoglu*, A. Folch*. “Editorial for the Special Issue on 3D Printed Microfluidic Devices” Micromachines 9 (11), 609 (2018).
3. R. Amin, A. Joshi, & S. Tasoglu*. “Commercialization of 3D-printed microfluidic devices” Journal of 3D Printing in Medicine 1(2) 85-89 (2017).
4. R. Amin, S. Knowlton, A. Hart, B. Yenilmez, F. Ghaderinezhad, S. Katebifar, M. Messina, A. Khademhosseini and S. Tasoglu*, “3D-Printed Microfluidic Devices”, Biofabrication, 8(2), 22001 (2016).